. Author manuscript; available in PMC: 2016 Nov 28.

Published in final edited form as: Mol Psychiatry. 2015 Feb 17;20(6):661–670. doi: 10.1038/mp.2015.4

Table 1.

Genomewide association studies of lithium response

Study	Subjects	Assessment of lithium response	Results	Comments
STEP-BD¹⁶⁴	458 discovery and 359 replication sample	Time to recurrence	Ch 10 (rs10795189) p=5.5×10⁻⁷ in discovery sample	<60% of subjects on lithium monotherapy; <40% treated for 1 year or more
Squassina et al.¹⁶⁵	52 (26 R and 26 NR)	Retrospective scale	Ch 17 (ACCN1 gene; rs11869731 p=7.21×10⁻⁶	Small sample size
Chen et al.¹⁵²	294 discovery (185 R, 109 NR) and replication (50 R, 50 NR)	Retrospective scale; inter-rater reliability reported	Ch 3 (GADL1 gene; rs17026688, rs17026651) p=1.66×10⁻⁴⁹ in combined sample	The associated variant not present in Caucasians
ConLiGen¹⁶⁶	1217 (374 R, 843 NR)	Retrospective scale; inter-rater reliability reported	Ch 2 (SLC4A10 gene) p=1.95×10⁻⁶	Preliminary results; data collection and analyses continuing
Bergen et al.¹⁶⁷	940 (64% R, 28% PR, 8% NR)	Self-report	Ch 17 (GAS gene; rs12601160) p=2.20×10⁻⁶	Preliminary results; data collection and analyses continuing

R responders, PR partial responders, NR non-responders