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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Methods Mol Biol. 2017;1506:3–16. doi: 10.1007/978-1-4939-6506-9_1

Table 1. Summary of clinical hepatocyte transplantation in pediatric acute liver failure.

Etiology Age Effect/outcome Reference
Drug induced 16 years Ammonia reduction/death 2 days post-HT Soriano et al. [40]
12 years Ammonia reduction/death 7 days post-HT
10 years Ammonia reduction/death 7days post-HT
13 years Death 4 days post-HT Strom et al. [41]
14 years Ammonia reduction and improved encephalopathy/OLT 1 day post-HT Fisher and Strom [3]

Idiopathic 3 years5 years Ammonia reduction and improved encephalopathy in both:Full recovery and immunosuppression weaned Successful bridge to OLT 4 days post-HT Soriano et al. [40]
3.5 months No clear benefit/OLT 1 day post-HT Sterling et al. [42]
8 years Intraperitoneal injection of fetal hepatocytes/full recovery Habibullah et al. [16]

Viral induced 4 years Ammonia reduction and improved encephalopathy/intracranial hypertension in day 2 Fisher and Strom [3]
3 weeks Death 11 days post-HT Meyburg et al. [43]

Table modified with permission from [39]

OLT orthotopic liver transplantation, HT hepatocyte transplant