Table 1. Summary of clinical hepatocyte transplantation in pediatric acute liver failure.
| Etiology | Age | Effect/outcome | Reference |
|---|---|---|---|
| Drug induced | 16 years | Ammonia reduction/death 2 days post-HT | Soriano et al. [40] |
| 12 years | Ammonia reduction/death 7 days post-HT | ||
| 10 years | Ammonia reduction/death 7days post-HT | ||
| 13 years | Death 4 days post-HT | Strom et al. [41] | |
| 14 years | Ammonia reduction and improved encephalopathy/OLT 1 day post-HT | Fisher and Strom [3] | |
|
| |||
| Idiopathic | 3 years5 years | Ammonia reduction and improved encephalopathy in both:Full recovery and immunosuppression weaned Successful bridge to OLT 4 days post-HT | Soriano et al. [40] |
| 3.5 months | No clear benefit/OLT 1 day post-HT | Sterling et al. [42] | |
| 8 years | Intraperitoneal injection of fetal hepatocytes/full recovery | Habibullah et al. [16] | |
|
| |||
| Viral induced | 4 years | Ammonia reduction and improved encephalopathy/intracranial hypertension in day 2 | Fisher and Strom [3] |
| 3 weeks | Death 11 days post-HT | Meyburg et al. [43] | |
Table modified with permission from [39]
OLT orthotopic liver transplantation, HT hepatocyte transplant