Table 3.

mRNA expression levels of candidate genes after HDAC5 knockdown in SSc ECs compared to control siRNA-treated cells (mean +/− S.D).

Gene	Expression fold change vs. control (n=7 patient pairs)	p-value
ID2	2.188 ± 1.002	0.02
CTNNAL1	2.064 ± 0.880	0.03
MBP	4.073 ± 5.550	0.03
PVRL2	3.091 ± 1.600	0.02
CYR61	2.423 ± 1.562	0.03
FSTL1	2.542 ± 1.514	0.04
FSTL3	4.586 ± 4.358	0.03
SQSTM1	2.080 ± 1.419	0.04
KRAS	1.884 ± 1.250	0.08
SOD2	3.446 ± 2.591	0.08
NINJ1	1.849 ± 1.469	0.55
THSD1	1.762 ± 1.106	0.43
FGF18	1.023 ± 1.576	0.35
FAM198	1.086 ± 0.793	0.86
TAB2	1.532 ± 1.017	0.75
TMEM18	1.339 ± 0.688	0.99
IQSEC1	1.301 ± 0.661	0.22
NFYA	1.757 ± 1.622	0.19
ETV5	2.453 ± 2.228	0.83
EDEM1	1.342 ± 0.685	0.35
HSF2	1.807 ± 1.062	0.14
MAP3K3	1.417 ± 0.898	0.55
PRDX3	1.365 ± 0.664	0.31
HSPA2	1.152 ± 0.720	0.31
MATN1	N.D.

N.D.=Not Detected