Analysis of the systemic effects of PTH release from the local delivery devices. (A) Representative μCT reconstructions of the tibiae from different treatment groups; (B) Trabecular bone volume; (C) Serum P1NP level and (D) TRAP5b level measured using ELISA kits. n=6~9 per group, *P<0.05, **P<0.005, #P<0.05, ##P<0.005, ###P<0.001.