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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Parkinsonism Relat Disord. 2016 Jul 20;31:79–86. doi: 10.1016/j.parkreldis.2016.07.009

Table 2.

Mean (±SEM) cerebrospinal fluid concentrations (pmol/mL) of Catechols in patient groups with synucleinopathy and control subjects.

Catechol MSA-P PD PAF Control
DOPA 2.97 ± 0.13 3.20 ± 0.20 2.82 ± 0.19 3.49 ± 0.11
(32) (24) (18) (32)
0.006 n.s. 0.0019
Cys-DOPA 1.03 ± 0.08 1.14 ± 0.10 1.02 ± 0.08 0.92 ± 0.06
(32) (24) (18) (32)
n.s. n.s. n.s.
DA 0.06 ± 0.01 0.07 ± 0.02 0.12 ± 0.05 0.08 ± 0.02
(32) (24) (18) (32)
n.s. n.s. n.s.
Cys-DA 0.11 ± 0.02 0.09 ± 0.01 0.06 ± 0.01 0.08 ± 0.01
(32) (24) (18) (32)
n.s. n.s. n.s.
DOPAC 0.89 ± 0.08 0.94 ± 0.09 1.43 ± 0.10 1.60 ± 0.12
(32) (24) (18) (32)
<0.0001 <0.0001 n.s.
NE 0.47 ± 0.05 0.64 ± 0.07 0.65 ± 0.13 0.87 ± 0.08
(32) (24) (18) (32)
<0.0001 0.0562 0.0023
DHPG 7.57 ± 0.36 8.88 ± 0.54 7.40 ± 0.73 10.92 ± 0.56
(32) (24) (18) (32)
0.0001 0.0286 <0.0001
EPI N.D. N.D. N.D. N.D.

Notes:

Numbers in italics are p values for the difference from Control (Fisher's Least Significant Difference post-hoc test applied to log-transformed data).

Numbers in parentheses are numbers of data points.

Abbreviations: Cys-DA = cysteinyl-dopamine; Cys-DOPA = cysteinyl-DOPA; DA = dopamine; DHPG = 3,4-dihydroxyphenylglycol; DOPAC = 3,4-dihydroxyphenylacetic acid; EPI = epinephrine; MSA-P = parkinsonian multiple system atrophy; NE = norepinephrine; N.D. = not detected; n.s. = not statistically significant; PAF = pure autonomic failure; PD=Parkinson.