Color photographs, spectral-domain optical coherence tomography (SD OCT)—derived
retinal pigment epithelium-drusen complex (RPEDC) thickness maps, and SD OCT B-scans for
baseline (top row), year 2 (middle row), and year 3
(bottom row) for a single study eye. The markings follow the same
designations as for Figure 1. Seven optical coherence
tomography—reflective drusen substructures (ODS)-centered regions of interest
(ROIs) are shown on the color photograph and SD OCT—derived thickness map at
baseline (white circles, top row) and project to the
white lines on the B-scan. The white circles in the
middle and bottom rows track the locations of these ROIs (not new ODS) at
years 2 and 3. The ODS locations at baseline are amidst drusen and some pigment clumping
in this eye, without a unique characteristic on color photograph. Two low-reflective cores
(ODS subtype, black arrows) are visible on the B-scan at baseline. Note
that baseline positions of these ODS on the thickness maps and B-scans rapidly progress to
drusen collapse at year 2 and geographic atrophy (GA) at year 3.