Table 6. Cross-sectional Study: Baseline Variables in 0.5-mm Diameter Region of Interest with Optical Coherence Tomography–Reflective Drusen Substructures Compared with Matched Region of Interest without Optical Coherence Tomography–Reflective Drusen Substructures in Same Eye at Baseline.
| Overall Comparison | Subtype Comparison: Regions with ODS Subtype versus Regions with No ODS | |||||||||||
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| Regions with ODS | Regions with No ODS | L-type | H-type | C-type | S-type | |||||||
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| No. of ROIs | 114 | 114 | 35 | 52 | 20 | 7 | ||||||
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| Mean (SD) | Mean (SD) | P Value* | Mean (SD) | P Value | Mean (SD) | P Value | Mean (SD) | P Value | Mean (SD) | P Value | ||
| Drusen Load | RPE drusen complex (mm3)† | 0.0088 (0.0047) | 0.0086 (0.0047) | 0.563 | 0.0087 (0.0052) | 0.022 | 0.0087 (0.0047) | 0.041 | 0.0086 (0.0028) | 0.005 | 0.0100 (0.0054) | 0.397 |
| OCT drusen (mm3) | 0.0018 (0.0038) | 0.0017 (0.0038) | 0.930 | 0.0019 (0.0043) | 0.105 | 0.0018 (0.0040) | 0.503 | 0.0013 (0.0014) | 0.010 | 0.0028 (0.0045) | 0.419 | |
| Preatrophy | RAT (× 10−3) (mm3) | 0.0100 (0.0200) | 0.0100 (0.0300) | 0.576 | 0.0051 (0.0158) | 0.085 | 0.0088 (0.0226) | 0.134 | 0.0059 (0.0227) | 0.298 | 0.00 (0.00) | 0.280 |
| Prop (%) | Prop (%) | Prop (%) | Prop (%) | Prop (%) | Prop (%) | |||||||
| PRL thinning above drusen | 23/114 (20.17) | 36/114 (31.58) | 0.053 | 4/35 (11.43) | 0.052 | 11/52 (21.15) | 0.180 | 7/20 (35.00) | 0.480 | 1/7 (14.29) | 0.317 | |
| PRL thinning without drusen | 14/114 (12.28) | 5/114 (4.39) | 0.020 | 3/35 (8.57) | – | 6/52 (11.54) | 0.480 | 5/20 (25.00) | 0.046 | 0/7 (0.00) | – | |
| Ellipsoid zone loss | 89/114 (78.07) | 78/114 (68.42) | 0.056 | 27/35 (77.14) | 0.058 | 39/52 (75.00) | 0.346 | 16/20 (80.00) | 1.00 | 7/7 (100.00) | – | |
| RPE atrophy | 16/114 (14.04) | 16/114 (14.04) | 0.275 | 5/35 (14.29) | 0.564 | 5/52 (9.62) | 0.052 | 5/20 (25.00) | 1.00 | 1/7 (14.29) | – | |
| Choroidal increased signal | 27/114 (23.68) | 15/114 (13.16) | 0.029 | 8/35 (22.86) | 0.103 | 11/52 (21.15) | 0.439 | 6/20 (30.00) | 0.257 | 2/7 (28.57) | 0.380 | |
| Neovascular | IRF | 0/114 (0.00) | 0/114 (0.00) | – | 0/35 (0.00) | – | 0/52 (0.00) | – | 0/20 (0.00) | – | 0/7 (0.00) | – |
| SRF | 5/114 (4.39) | 4/114 (3.51) | 0.317 | 2/35 (5.71) | – | 1/52 (1.92) | – | 2/20 (10.00) | – | 0/7 (0.00) | – | |
| Other | Subretinal lesion | 0/114 (0.00) | 0/114 (0.00) | – | 0/35 (0.00) | – | 0/52 (0.00) | – | 0/20 (0.00) | – | 0/7 (0.00) | – |
| Hyperreflective foci | 52/114 (45.61) | 19/114 (16.67) | <0.0001 | 15/35 (42.86) | 0.1336 | 27/52 (51.92) | <0.0001 | 7/20 (35.00) | 0.2568 | 3/7 (42.86) | 0.3173 | |
IRF = intraretinal fluid; OCT = optical coherence tomography; ODS = optical coherence tomography–reflective drusen substructures; PRL = photoreceptor layer; RAT = retinal pigment epithelium drusen complex abnormal thinning; ROI = region of interest; RPE = retinal pigment epithelium; SD = standard deviation; SRF = subretinal fluid.
*
Paired t test using generalized estimating equations (GEEs) and simple McNemar's test with alpha value = 0.05; “–” means test could not be carried out due to asymmetric table.
†
The RPEDC volume was 1 criteria used to match each ODS ROI with corresponding control ROI.