. Author manuscript; available in PMC: 2017 Dec 1.

Published in final edited form as: Ophthalmology. 2016 Oct 25;123(12):2554–2570. doi: 10.1016/j.ophtha.2016.08.047

Table 2b. Study Outcomes for Regional Analysis.

	Outcome	Source Modality^†	Definition	Variable Type^‡
Drusen Load	RPE drusen complex volume (RPEDC, mm³)	SD OCT	Drusen-RPE combined volume; volume between the inner border of the RPE and outer border of Bruchs membrane¹⁴	Continuous
	OCT drusen volume (mm³)	SD OCT	Volume of RPEDC abnormal thickening ≥3 SD from the mean of a normative dataset for each pixel location in non-AMD eyes^14,18	Continuous
Preatrophy^*	RPEDC abnormal thinning volume (RAT, ×10⁻³, mm³)	SD OCT	Volume of RPEDC abnormal thinning ≤2 SD from the mean of a normative dataset for each pixel location in non-AMD eyes^14,18	Continuous
	PRL thinning above drusen	SD OCT	Loss of volume of region between inner aspect of the outer plexiform layer and inner border of RPEDC above drusen compared with adjacent tissue; measured by outer plexiform layer dipping toward RPE	Binary
	PRL thinning without drusen	SD OCT	Loss of volume of region between inner aspect of the outer plexiform layer and inner border of RPEDC not associated with drusen compared with adjacent tissue; measured by outer plexiform layer dipping toward RPE	Binary
	Ellipsoid zone loss	SD OCT	Ellipsoid zone loss or disruption in the presence or absence of other pathologies	Binary
	RPE atrophy	SD OCT	A complete absence of RPE or contour break with PRL loss	Binary
	Choroidal increased signal	SD OCT	Increased choroidal signal relative to adjacent areas	Binary
Neovascular	IRF	SD OCT	Round or oval hyporeflective areas within the retinal layers usually located within the nuclear layers	Binary
	SRF	SD OCT	Area of low reflectivity (less than or comparable to the vitreous gel) between the outer surface of the retina and the RPE	Binary
Other	Subretinal lesions	SD OCT	CNV and pathology occurring beneath the layers of neurosensory retina and anterior to the RPE, including reticular pseudodrusen, subretinal hyperreflective material, presumed vitelliform lesion, scar, and hemorrhage^20,21	Binary
	Hyperreflective foci	SD OCT	Focal, well-circumscribed hyperreflective lesions within the neurosensory retina overlying drusen not associated with intraretinal vessels¹⁵	Binary

AMD = age-related macular degeneration; CNV = choroidal neovascularization; DA = disc area; ETDRS = Early Treatment Diabetic Retinopathy Study; IRF = intraretinal fluid; RAT = retinal pigment epithelium drusen complex abnormal thinning; RPE = retinal pigment epithelium; RPEDC = retinal pigment epithelium drusen complex; SD = standard deviation; SD OCT = spectral-domain optical coherence tomography; SRF = subretinal fluid.

Primary study outcomes.

^†

Derived from SD OCT imaging; color photo = derived from color fundus photo using Wisconsin Age-Related Maculopathy Grading System.¹

^‡

Continuous = measured by semiautomated segmentation on SD OCT (previously validated and described)^23,25 or DA units²⁴ on CFP; binary = present or absent, as determined by qualitative grading on SD OCT or CFP.