Fig. 1. (A) Oxazolone-treated atopic dermatitis (Ox-AD) mice groups treated with pH 3.5 vinegar cream, pH 5.0 vinegar cream, or pH 3.5 hydrogen chloride (HCl) cream exhibited fewer AD-like lesions than mice treated with only vehicle cream (pH 5.5) or neutralized vinegar cream (pH 7.4). (B) Eczema scores were significantly higher in the vehicle group than in the acidic cream treatment groups. There was no difference in the eczema scores between vehicle group and neutralized vinegar cream treated group. Eczema scores were determined by the sum of the severity of erythema, edema, and lichenification. Severity: absent (0), mild (1), moderate (2), and severe (3). Results are shown as the mean±standard error of the mean. ^**p<0.05, ^***p<0.001.