Table 4.
Relations between the anthropometric parameters: WC, BMI, and ABP; biochemical parameters: TST, FTS, SHBG, E2, TG, TCh, LDL, HDL, WC, and the FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 gene polymorphisms, evaluated by ANOVA (n=272)
| Variable |
FTO rs9939609
|
MC4R rs17782313
|
PPARγ rs1801282
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| AA + TA | TT | P-value | CC + CT | TT | P-value | CG + GG | CC | P-value | |
| BMI | 27.99±4.25 | 28.30±4.94 | 0.61 | 28.62±4.66 | 27.75±4.32 | 0.12 | 27.67±4.09 | 28.25±4.16 | 0.32 |
| SBP (mmHg) | 130.33±18.99 | 132.37±19.57 | 0.44 | 133.58±20.22 | 129.29±18.36 | 0.07 | 131.45±20.10 | 130.57±18.71 | 0.72 |
| DBP (mmHg) | 82.08±11.24 | 83.43±12.53 | 0.40 | 83.48±11.61 | 81.82±11.54 | 0.25 | 82.44±11.11 | 82.42±11.8 | 0.98 |
| TST (ng/mL) | 3.66±1.65 | 3.73±1.61 | 0.78 | 3.72±1.79 | 3.66±1.55 | 0.77 | 3.72±1.79 | 3.65±1.68 | 0.77 |
| FTS (pg/mL) | 105.60±59.10 | 115.05±66.59 | 0.26 | 114.05±62.52 | 104.59±60.33 | 0.22 | 114.05±62.52 | 106.22±61.22 | 0.22 |
| SHBG (nmol/L) | 43.50±23.19 | 47.54±24.15 | 0.22 | 44.13±27.87 | 44.83±20.61 | 0.81 | 46.18±21.47 | 43.83±24.35 | 0.45 |
| E2 (pg/mL) | 35.56±22.82 | 39.88±23.14 | 0.17 | 37.23±22.16 | 36.36±23.43 | 0.76 | 34.66±20.79 | 37.60±23.86 | 0.33 |
| DHEAS (μg/mL) | 1.37±0.78 | 1.52±0.78 | 0.17 | 1.44±0.84 | 1.38±0.75 | 0.59 | 1.43±0.78 | 1.39±0.78 | 0.70 |
| TG (mg/dL) | 143.89±77.53 | 145.00±90.27 | 0.92 | 146.95±75.57 | 142.59±83.86 | 0.67 | 142.73±77.39 | 144.85±82.56 | 0.84 |
| TCh (mg/dL) | 207.30±54.97 | 223.07±57.14 | 0.05* | 211.57±59.93 | 211.24±57.03 | 0.96 | 215.28±54.86 | 209.55±59.44 | 0.45 |
| LDL (mg/dL) | 136.18±51.57 | 153.04±62.48 | 0.03* | 140.93±57.36 | 140.29±53.71 | 0.93 | 144.32±49.37 | 138.76±57.41 | 0.44 |
| HDL (mg/dL) | 42.95±12.55 | 41.37±12.47 | 0.36 | 42.42±13.17 | 42.61±12.9 | 0.91 | 42.43±12.84 | 42.58±12.42 | 0.92 |
| WC (cm) | 100.85±11.15 | 102.53±13.09 | 0.3 | 103.91±12.61 | 99.77±10.86 | 0.005* | 100.5±11.11 | 101.64±11.95 | 0.45 |
Notes:
Statistically significant. Data presented as AM ± SD.
Abbreviations: WC, waist circumference; BMI, body mass index; ABP, arterial blood pressure; TST, total testosterone; FTS, free testosterone; SHBG, sex hormone-binding globulin; E2, estradiol; TG, triglyceride; TCh, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; FTO, fat mass and obesity; MC4R, melanocortin 4 receptor; PPARγ, peroxisome proliferator-activated receptor; ANOVA, analysis of variance; SBP, systolic blood pressure; DBP, diastolic blood pressure; DHEAS, dehydroepiandrosterone sulfate; A, adenine; T, thymine; C, cytosine; G, guanine.