Table 5.

The influence of recessive FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 genotypes on metabolic, hormonal, and anthropometric indices by means of logistic regression

Variable	FTO rs9939609, TT vs AA + TA			MC4R rs17782313, TT vs CC + CT			PPARγ rs1801282, CC vs CG + GG
	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
BMI	1.016	0.956–1.079	0.61	0.957	0.906–1.012	0.12	1.031	0.972–1.094	0.31
SBP (mmHg)	1.006	0.992–1.02	0.44	0.988	0.976–1.001	0.07	0.998	0.984–1.011	0.72
DBP (mmHg)	1.01	0.987–1.034	0.49	0.988	0.967–1.009	0.25	1.00	0.978–1.022	0.99
TST (ng/mL)	1.024	0.868–1.207	0.78	0.978	0.842–1.137	0.77	0.972	0.832–1.135	0.72
FTS (pg/mL)	1.002	0.998–1.007	0.27	0.998	0.994–1.002	0.22	0.998	0.994–1.003	0.47
SHBG (nmol/L)	1.007	0.996–1.018	0.22	1.001	0.991–1.012	0.81	0.996	0.985–1.007	0.44
E2 (pg/mL)	1.008	0.996–1.02	0.18	0.998	0.988–1.009	0.76	1.006	0.994–1.017	0.33
DHEAS (μg/mL)	1.268	0.9–1.786	0.17	0.917	0.669–1.256	0.59	0.936	0.676–1.297	0.69
TG (mg/dL)	1.00	0.997–1.004	0.92	0.99	0.996–1.002	0.66	1.00	0.997–1.004	0.84
TCh (mg/dL)	1.005	1.00–1.009	0.05*	1.00	0.996–1.004	0.96	0.998	0.994–1.003	0.45
LDL (mg/dL)	1.006	1.001–1.011	0.03*	1.00	0.995–1.004	0.93	0.998	0.994–1.003	0.44
HDL (mg/dL)	0.99	0.968–1.012	0.36	1.001	0.982–1.021	0.91	1.001	0.981–1.022	0.92
WC (cm)	1.012	0.989–1.036	0.29	0.97	0.949–0.991	0.006*	1.009	0.986–1.031	0.45

Note:

^*Statistically significant.

Abbreviations: FTO, fat mass and obesity; MC4R, melanocortin 4 receptor; PPARγ, peroxisome proliferator-activated receptor; OR, odds ratio; CI, confidence interval; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TST, total testosterone; FTS, free testosterone; SHBG, sex hormone-binding globulin; E₂, estradiol; DHEAS, dehydroepiandrosterone sulfate; TG, triglyceride; TCh, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; WC, waist circumference; A, adenine; T, thymine; C, cytosine; G, guanine.