Figure 2.
The acute HR-, TPR-, and MBP-response to KV7-inhibitors and -openers. Preferred drug selectivity is indicated by symbol legends. The drugs were given alone or, in SHR, in combination as indicated. The immediate HR- and MBP-response was recorded at the initial TPR-peak/nadir-response. Significant changes in response to channel inhibitors/openers compared to that following the sham-injection of PBS in the control groups were detected as indicated (asterix below/above columns). Involvement of ganglion transmission, sympathetic nerve norepinephrine release and M2AchR activity in the response to Kv-drug was further analyzed in SHR by prior administration of hexamethonium, reserpine or methoctramine, respectively (* in bar). * above columns—P ≤ 0.0167 in WKY and 0.0056 in SHR. * in brackets—P ≤ 0.0167 for XE-991 (none detected) and 0.025 for retigabine.