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. 2016 Nov 29;7:584. doi: 10.3389/fphys.2016.00584

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Copyright © 2016 Berg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The HR-response to 3,4-DAP after pre-treatment with Kv7-openers. Retigabine (K_V7.2-7.5) and ICA-27243 (K_V7.2-7.3) were administered alone or after reserpine, as indicated by symbol legends. Significant responses (* within symbol) and group differences (* in brackets) at about 1 (recorded at the TPR-peak-response) and at 25 min were located as indicated. Comparisons were made between corresponding control and experimental groups, and between groups pre-treated with retigabine/ICA-27243 alone and reserpine+retigabine/ICA-27243. *P < 0.025 after curve analyses.