Figure 5.

The TPR-response to 3,4-DAP in WKY (A) and SHR (B–D) after pre-treatment with Kv7-opener or -inhibitor, alone or combined with hexamethonium, reserpine or methoctramine, as indicated by symbol legends. Significant responses (* within symbol) and group differences (* in brackets) at about 1 (at the TPR-peak-response) and at 25 min were located as indicated. Comparisons were made between corresponding control and experimental groups, and between groups pre-treated with corresponding channel opener/inhibitor alone and hexamethonium/reserpine/methoctramine+channel opener/inhibitor. *P < 0.025 after curve analyses.