. 2016 Nov 3;33(12):2200–2210. doi: 10.1007/s12325-016-0433-3

Table 1.

US OA demographic values

Variable	Past estimates (year)	2015 estimate
US symptomatic knee OA prevalence	9,900,000 (2010)^a	12,338,273
US OA incidence	768,494 (1995)^b	605,598
US TKA prevalence	4,000,000 (2013)^c	5,240,455
US TKA incidence	671,374 (2012)^d	–
US death rate in adults >35	1.026% (2007)^e	–
K–L grade 1	30.0% (2009)^f	2,130,382
K–L grade 2	27.3% (2009)^f	1,939,724
K–L grade 3	29.2% (2009)^f	2,074,428
K–L grade 4	13.4% (2009)^f	953,283
Total eligible patients	–	4,014,153
Current Euflexxa use	276,168 (2014)^g	276,168
Current other IA-HA use	962,185 (2014)^g	962,185
Total eligible non-HA users	–	3,051,968

^aAAOS, 2010

^bOliveria, 1995 [13]

^cWeinstein, 2013 [14]

^dHealthcare Cost and Utilization Project, 2015 [15]

^eCenters for Disease Control and Prevention, 2015 [18]

^fMulticenter Osteoarthritis Study, 2010 [16]

^gIMS, 2014 [17]