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. 2016 Sep 24;64(5):1133–1141. doi: 10.1007/s12026-016-8870-2

Fig. 1.

Fig. 1

Adenosine pathway mediates immune suppression. A scheme illustrates the generation of adenosine and the adenosine receptor signaling pathway that mediates immune suppression. Adenosine is generated from degradation of ATP by CD39 & CD73. The adenosine pathway mediates the immune suppression by regulating the function of immune cells, such as T cells, dendritic cells and macrophages