The majority of coronary events generally occur at dawn and in the early morning, a timing that may also be relevant to their prevention.

The risk of acute myocardial events is significantly influenced by prothrombotic, hormonal, and hemodynamic processes that occur in the human body according to circadian rhythms.

While the blood pressure-lowering effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs) should be considered, so too should all other differences that may protect against a plaque rupture leading to myocardial infarction.