Table 4.

Variants in the 3′‐UTR affecting polyadenylation

Gene	Variant	Mechanism	Expression/effect on protein	Cancer type	Reference
CCND1	Several genomic deletions in 3′‐UTR (N/A)	Premature polyadenylation	Increase by enhanced stability of truncated mRNA (lacking AU‐rich elements, loss of miR‐BS)	Mantle cell lymphoma (oncogenic risk)	Wiestner et al (2007)
	Small aberration within 3′‐UTR (320 bp from stop codon: single base insertion (A at position 1344), small deletion (3 bp at position 1,344–46), duplication in repetitive element in 3′‐UTR (N/A)	Creation of APA signals
MSH6	Duplication of 20 bp close to the polyadenylation site (g)	Decreased efficiency of polyadenylation	Decrease	Lynch syndrome	Decorsiere et al (2012)
TP53	rs78378222 A/C (g: SNP)	Change within polyadenylation signal	Decrease	Cutaneous basal cell carcinoma, prostate cancer, colorectal adenoma, glioma	Stacey et al (2011)
PSMD8 TM9SF3 CD59 ANKH CIAO1 SRSF5 MRSP16 NDUFA6	(N/A)	APA Differential usage of polyadenylation sites	Increase by enhanced stability of truncated mRNA due to miR‐BS loss	Small intestinal neuroendocrine tumor	Rehfeld et al (2014)

Mutational status as indicated in bold in brackets; s, somatic; g, germline; N/A, not available.

APA, alternative polyadenylation.