Table 1.
Association of 34 selected SNPs with prostate cancer risk
| Locus | SNP | Romanian population | Reference studies | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Risk allele | Cases | RAF cases | Controls | RAF controls | OR (95% CI) | P a value | Reported RAF | Reported per allele OR | Mapped gene | Reference | ||
| 2p21 | rs1465618 | A | 974 | 0.26 | 1019 | 0.23 | 1.15 (0.99–1.33) | 0.069 | 0.23 | 1.08 (1.03–1.12) | Intronic THADA | Eeles 2009 |
| 2p15 | rs721048 | A | 956 | 0.16 | 1014 | 0.14 | 1.13 (0.95–1.36) | 0.164 | 0.19 | 1.15 (1.10–1.21) | Intronic in EHBP1 | Gudmundsson 2008 |
| 2q31.1 | rs12621278 | A | 977 | 0.97 | 1020 | 0.97 | 1.06 (0.72–1.56) | 0.778 | 0.94 | 1.33 (1.25–1.43) | Intronic in ITGA6 | Eeles 2009 |
| 3p12.1 | rs2660753 | C | 953 | 0.83 | 1020 | 0.82 | 1.08 (0.91–1.27) | 0.401 | 0.11 | 1.18 (1.06–1.31) | Intergenic | Eeles 2008 |
| 3q21.3 | rs10934853 | A | 968 | 0.30 | 1020 | 0.29 | 1.04 (0.91–1.20) | 0.554 | 0.28 | 1.12 (1.08–1.16) | Intergenic EEFSEC | Gudmundsson 2009 |
| 4q22.3 | rs12500426 | C | 963 | 0.49 | 1021 | 0.47 | 1.08 (0.95–1.22) | 0.240 | 0.46 | 1.08 1.05–1.12) | Intronic in PDLIM5 | Eeles 2009 |
| 4q22.3 | rs17021918 | C | 967 | 0.66 | 1013 | 0.65 | 1.02 (0.89–1.16) | 0.789 | 0.65 | 1.11 (1.08–1.15) | Intronic in PDLIM5 | Eeles 2009 |
| 4q24 | rs7679673 | C | 969 | 0.56 | 1012 | 0.52 | 1.20 (1.06–1.37) | 0.0037 | 0.55 | 1.1 (1.06–1.14) | TET2 | Eeles 2009 |
| 5p15.33 | rs2736098 | G | 943 | 0.72 | 1006 | 0.69 | 1.15 (1.00–1.33) | 0.045 | 0.26 | 1.13 (1.06–1.21) | TERT | Rafnar 2009 |
| 5p15.33 | rs401681 | T | 973 | 0.41 | 1016 | 0.40 | 1.08 (0.95–1.23) | 0.258 | 0.55 | 1.07 (1.03–1.11) | CLPTM1L | Rafnar 2009 |
| 6q25.3 | rs9364554 | T | 946 | 0.27 | 999 | 0.21 | 1.35 (1.16–1.57) | 0.000076 | 0.29 | 1.17 (1.08–1.26) | Intronic in SLC22A3 | Eeles 2008 |
| 7p15.2 | rs10486567 | G | 962 | 0.81 | 1015 | 0.77 | 1.32 (1.12–1.54) | 0.00046 | 0.77 | 1.12 (1.02–1.25) | Intronic in JAZF1 | Thomas 2008 |
| 7q21.3 | rs6465657 | C | 957 | 0.43 | 1019 | 0.42 | 1.03 (0.91–1.17) | 0.652 | 0.46 | 1.12 (1.05–1.20) | Intronic in LMTK2 | Eeles 2008 |
| 8p21.2 | rs1512268 | A | 969 | 0.48 | 1014 | 0.45 | 1.13 (1.00–1.28) | 0.056 | 0.45 | 1.18 (1.14–1.22) | NKX3.1 | Eeles 2009 |
| 8q24.21 | rs16901979 | A | 955 | 0.04 | 1007 | 0.03 | 1.58 (1.11–2.27) | 0.0098 | 0.03 | 1.79 (1.36–2.34) | Intergenic POU5F1B | Gudmundsson 2007 |
| 8q24.21 | rs16902094 | G | 949 | 0.17 | 1007 | 0.14 | 1.28 (1.07–1.52) | 0.0056 | 0.15 | 1.21 (1.15–1.26) | Intergenic POU5F1B | Gudmundsson 2009 |
| 8q24.21 | rs445114 | T | 950 | 0.66 | 1006 | 0.59 | 1.33 (1.18–1.52) | 0.000013 | 0.64 | 1.14 (1.10–1.19) | Intergenic POU5F1B | Gudmundsson 2009 |
| 8q24.21 | rs6983267 | G | 955 | 0.54 | 1014 | 0.51 | 1.15 (1.01–1.30) | 0.032 | 0.50 | 1.26 (1.13–1.41) | Intergenic POU5F1B | Yeager 2007 |
| 8q24.21 | rs1447295 | A | 968 | 0.12 | 1009 | 0.09 | 1.27 (1.03–1.57) | 0.025 | 0.09 | 1.62 (1.43–1.77) | Intergenic CASC8 | Gudmundsson 2007 |
| 10q11.23 | rs10933994 | T | 964 | 0.45 | 996 | 0.39 | 1.28 (1.13–1.46) | 0.00015 | 0.40 | 1.25 (1.17–1.34) | Promoter of MSMB | Eeles 2008. Thomas 2008 |
| 10q26.13 | rs4962416 | C | 955 | 0.32 | 996 | 0.28 | 1.19 (1.03–1.36) | 0.016 | 0.27 | 1.17 (1.05–1.30) | Intronic in CTBP2 | Thomas 2008 |
| 11p15.5 | rs7127900 | A | 968 | 0.22 | 1019 | 0.18 | 1.30 (1.11–1.52) | 0.0011 | 0.20 | 1.22 (1.17–1.27) | TH ‐ ASCL2 | Eeles 2009 |
| 11q13.2 | rs12418451 | A | 939 | 0.35 | 976 | 0.30 | 1.22 (1.06–1.40) | 0.0047 | 0.28 | NR | Zheng 2009 | |
| 11q13.3 | rs11228565 | A | 961 | 0.23 | 1004 | 0.20 | 1.18 (1.02–1.38) | 0.030 | 0.20 | 1.23 (1.16–1.31) | Intergenic MIR3164 ‐ MYEOV | Gudmundsson 2010 |
| 11q13.3 | rs10896450 | G | 969 | 0.54 | 1011 | 0.47 | 1.30 (1.14–1.47) | 0.000047 | 0.46 | 1.13 (1.06–1.21) | Gudmundsson 2009 | |
| 17p12 | rs4054823 | T | 964 | 0.54 | 1016 | 0.52 | 1.09 (0.95–1.23) | 0.226 | 0.54b | 1.13 (1.08–1.19)b | Xu 2010 | |
| 17q12 | rs11649743 | G | 969 | 0.84 | 1014 | 0.81 | 1.16 (0.89–1.37) | 0.080 | 0.80 | 1.28 (1.07–1.52) | Intronic in HNF1B | Sun 2008 |
| 17q12 | rs4430796 | A | 972 | 0.57 | 1017 | 0.52 | 1.22 (1.08–1.39) | 0.0022 | 0.49 | 1.22 (1.15–1.30) | Intronic in HNF1B | Gudmundsson 2007 |
| 17q24.3 | rs1859962 | G | 972 | 0.52 | 1017 | 0.50 | 1.08 (0.95–1.22) | 0.253 | 0.46 | 1.20 (1.14–1.27) | Intergenic CASC17 | Gudmundsson 2007 |
| 19q13.2 | rs8102476 | C | 952 | 0.61 | 993 | 0.60 | 1.06 (0.93–1.20) | 0.393 | 0.54 | 1.12 (1.08–1.15) | Intergenic | Gudmundsson 2009 |
| 19q13.33 | rs2735839 | G | 965 | 0.88 | 1003 | 0.85 | 1.23 (1.02–1.49) | 0.026 | 0.85 | 1.2 (1.10–1.33) | KLK3 ⁄ KLK3 | Eeles 2008 |
| 22q13.1 | rs9623117 | C | 879 | 0.23 | 987 | 0.23 | 1.00 (0.85–1.17) | 1.0 | 0.21 | 1.18 (1.11–1.26) | Intronic TNRC6B | Sun 2008 |
| 22q13.2 | rs5759167 | G | 918 | 0.57 | 933 | 0.53 | 1.16 (1.02–1.33) | 0.019 | NR | 1.16 (1.14–1.20) | Eeles 2009 | |
| Xp11.22 | rs5945572 | A | 916 | 0.41 | 1020 | 0.36 | 1.24 (1.03–1.49) | 0.024 | 0.35 | 1.23 (1.16–1.30) | NUDT11 | Gudmundsson 2008 |
a
P‐value uncorrected for multiple testing.
b
In aggressive versus non‐aggressive cases.
RAF: Risk allele frequency.