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Relative inhibition of pancreatic cancer and normal cell viabilities by the PCAIs and compared to current therapies
| EC50 (µM) | |||||
|---|---|---|---|---|---|
|
| |||||
| MIAPaCa-2 | Panc-1 | BxPC-3 | HPAF-II | HEK-293 | |
| NSL-BA-036 | 4.4 | 2.6 | 3.3 | 15 | 26 |
| NSL-BA-040 | 3.4 | 1.8 | 2.4 | 9.9 | 8 |
| NSL-BA-055 | 2.4 | 1.9 | 2.0 | 2.1 | > 50 |
| NSL-BA-056 | 5.1 | 3.3 | 7.3 | 11 | 24 |
| Erlotinib | > 50 | ND | ND | > 50 | ND |
| Gemcitabine | > 50 | ND | ND | > 50 | ND |
