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. 2016 Nov 1;6(11):2587–2598.

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FAM83D is upregulated in LUAD tissues and correlates with more aggressive clinical characteristics in TCGA dataset. A. FAM83D is significantly upregulated in LUAD tissues compared with adjacent normal tissues (P<0.0001). B and C. FAM83D was found to be positively correlated with Ki-67 (r = 0.7114, P<0.0001, n = 511) and DNA ploidy (P<0.0001) in LUAD tissues. D. Kaplan-Meier survival analysis indicated that higher FAM83D expression is associated with worse overall survival in LUAD patients (HR = 1.890, P = 0.0003). E. Multivariate Cox regression analysis revealed that high expression of FAM83D was an independent risk factor for reduced overall survival in LUAD patients (HR = 1.692, P = 0.006).