Figure 5.

FAM83D regulates cell cycle progression by influencing CCND1 and CCNE1 expression. A. Genes co-expressed with FAM83D are enriched in the “cell cycle” pathway according to KEGG and GO enrichment analysis. B and C. qRT-PCR and western blot showed CCND1 and CCNE1 were significantly decreased in sh-FAM83D transfected cells, while p21 and p27 were not significantly altered. D and E. Pearson test showed that CCND1 and CCNE1 were both positively correlated with FAM83D in LUAD tissues. *P<0.05, NS: No significance.