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. 2016 Nov 1;6(11):2599–2610.

Figure 2.

Figure 2

FPR2 expressed on cell membrane and FPR2-mediated colon cancer cell migration in response to the FPR2 ligand MMK-1. A. Immunofluorescence staining showing FPR2 expressed on cell membrane of human colon cancer cell lines and human embryonic kidney epithelial (HEK293) transfected with FPR2 (FPR2/293) and parent HEK293 cells are used as control. WiDr and HCT-116 are human colon carcinoma cells. Red: FPR2, Blue: DAPI. Scale Bar: 50 µm. B-E. Human colon cancer cell lines HCT116, KM12, HT29 and SW620 migrated in response to the FPR2 ligands MMK-1. The results are expressed as the mean ± SE of the chemotaxis index (CI), representing the fold increase in the number of migrated cells in response to chemoattractants over spontaneous cell migration (to control medium). *P < 0.05.