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. 2016 Nov 1;6(11):2631–2640.

Figure 4.

Figure 4

FGF2 reduced the inhibitory effects of miR-195 on CRC cells proliferation. A and B. SW480 cells were transfected with either FGF2 expression vector or its negative control, then cell viability and cell cycle were detected by MTT and flow cytometer; C and D. SW480 cells were transfected with miR-195 mimic or co-transfected with miR-195 mimic and FGF2 expression vector, then cell viability and the expression of CyclinB1, CyclinD1 and CDK2 were measured by MTT and Western blot. FGF2, Fibroblast growth factor 2; miR-195, microRNA-195; CRC, colorectal cancer; MTT, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide; CDK2, Cyclin-Dependent Kinase 2; *, P < 0.05; **, P < 0.01.