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miR-497/TKT axis promotes cisplatin chemoresistance through regulating generation of ROS. Effects of siRNAs or miR-497-mediated suppression of TKT on glucose uptake (A), lactate production (B), GSH levels (C), and ROS levels (D). The cell viability (E) and caspase-3/7 activity (F) in miR-497-treated HeLa and SiHa cells were measured in the presence of 1 mM GSH and 50 μg/ml cisplatin. *P < 0.05, **P < 0.01. ***P < 0.001.
