Table 4.
Multivariate analyses of factors associated with disease free survival (DFS) in test and validation cohort
| Variable | Test cohort (n = 266) | Validation cohort (n = 146) | ||
|---|---|---|---|---|
|
|
|
|||
| DFS hazard ratio (95% Cl) | P value | DFS hazard ratio (95% Cl) | P value | |
| Tumor site (stomach, small bowel, colon, others) | 1.633 (1.116-2.390) | 0.012* | 2.525 (1.450-4.397) | 0.001* |
| Tumor size (≤ 2, > 2 & ≤ 5, > 5 & ≤ 10, > 10 cm) | 2.354 (1.514-3.661) | < 0.001* | 3.012 (1.589-5.708) | 0.001* |
| Mitosis count (≤ 5, > 5 & ≤ 10, > 10/50 HPF) | 1.701 (1.163-2.488) | 0.006* | 2.885 (1.685-4.938) | < 0.001* |
| Tumor rupture (yes, no) | 1.969 (1.030-3.766) | 0.041* | 10.491 (3.785-29.079) | < 0.001* |
| Ki67 (negative, positive) | 2.972 (1.605-5.505) | 0.001* | - | - |
| DLK1 (negative, positive) | 1.486 (1.092-2.023) | 0.012* | 1.794 (1.078-2.984) | 0.024* |
*
P < 0.05.