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RNF31 is cleaved by the effector caspases caspase 3 and caspase 6. (A) WB analysis of A431 cells treated with Dox (3 μg/ml) or CPT (20 μM). (B and C) WB analysis of caspase 8-deficient Jurkat cells stimulated with Dox (3 μg/ml), CPT (20 μM), or 5-FU (20 μg/ml). (D) Results of an in vitro cleavage assay in which Myc-tagged RNF31 proteins were incubated with or without the indicated recombinant caspases for 2 h. C, caspase; IB, immunoblot.
