Figure 1.

The EEPO decreased rat cerebral ischemia-reperfusion injury. The male Sprague-Dawley rats were pretreated with phosphate PBS or different dose of EEPO (50, 100 and 200 mg/kg body weight defined as l-EEPO, m-EEPO and H-EEPO, respectively) once a day for seven days. one hour after the last administration, all rats were occluded the middle cerebral artery (MCA occlusion, MCAO) and after one hour all rats were carefully restored blood flow for 24 hours and used for experiments. The untreated rats which operated same as MACO group but not occluded the middle cerebral artery used as SAM group. Rats were sacrificed after over dose of chloral hydrate. The water level of rat brain tissue (A), the serum lactate dehydrogenase (LDH) (B) and the neurologic deficits (C) were determined (n=5, *P<0.05 vs PBS gourp). The represent pictures of the infarct area of brain tissue were shown in (D).