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. 2016 Nov 15;8(11):5098–5107.

Figure 4.

Figure 4

Naringin potentiates osteogenesis of BMSCs through up-regulating Foxc2 expression via the IHH signaling pathway. BMSCs were cultured in basal medium, OIM, OIM with 50 μg/mL naringin, and OIM with 50 μg/mL naringin in the absence or presence of 0.5 μM CPE for 14 days. A, B. Western blotting analysis of Foxc2 and IHH. C. Relative expression of FoxC2 in BMSCs was checked using real time PCR. D, E. Densitometric quantification of activated Foxc2 and IHH was performed. C. *P<0.05 versus the control group; **P<0.01 versus the OIM group; ***P<0.01 versus the 50 μg/mL group. D. *P<0.05 versus the control group; **P<0.01 versus the OIM group; ***P<0.05 versus the 50 μg/mL group.