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Competition of rabbit sera against V1V2 MAbs. (A and B) Results of rabbit sera competed against V2q MAb PG9 and V2p MAb CH58. As references, black curves from data of prebleeds and competition against the same MAb are included. (C and D) Competition against V2q MAb PG9 and V2p MAb CH58, as indicated, by sera from rabbits immunized with either structurally constrained V1V2(ZM109)-1FD6-Fc or the unconstrained V1V2(ZM109)-Fc.
