TABLE 1.
Characteristics of rhesus macaques included in the present study
| Macaque ID | Days postinfection | MHC genotypea and peptide | Virus | Plasma SIV RNA concn (log10 copies/ml) | Route of SIV infectionb | Phenotypee |
|||
|---|---|---|---|---|---|---|---|---|---|
| Ki67 | Perforin | Foxp3 | PD-1 | ||||||
| Rh2515 | 42 | A01 Gag-CM9 | SIVmac239 | 4.22 | IV | ND | − | + | + |
| Rh2516 | 42 | A01 Gag-CM9 | SIVmac239 | 5.55 | IV | + | ND | + | + |
| Rh2520 | 42 | A01 Gag-CM9 | SIVmac239 | 7.58 | IV | + | ND | + | + |
| Rh2306 | 84 | A01 Gag-CM9 | SIVmac239 | 6.15 | R | − | + | − | − |
| R03111 | 105 | A02 Nef-YY9 | SIVmac239 | 6.45 | R | − | + | − | − |
| R03094c | 154 | A01 Gag-CM9 | SIVmac239 | 6.20 | R | − | + | − | − |
| R03116 | 161 | A01 Gag-CM9 | SIVmac239 | 3.78 | R | − | + | − | − |
| 11-57 | 258 | A01 Gag-CM9 | SIVmac251 | 4.51 | V | +d | + | − | + |
| 11-45 | 272 | A01 Gag-CM9 | SIVmac251 | 6.26 | V | ND | + | + | + |
| JD85 | 272 | A01 Gag-CM9 | SIVmac251 | 4.56 | V | +d | ND | + | + |
| 11-89 | 349 | A01 Gag-CM9 | SIVmac251 | 5.15 | V | +d | + | + | + |
| 11-061 | 545 | A01 Gag-CM9 | SIVmac251 | 3.72 | V | +d | ND | + | + |
| Rhax18c | 546 | B08 Nef-RL10 | SIVmac239 | 4.97 | R | +d | + | − | + |
| R01106 | 567 | B08 Env-KL9 | SIVmac239 | 4.73 | R | +d | + | − | − |
| Rhau10 | 1,687 | B08 Nef-RL10 | SIVmac239 | 4.11 | IV | − | + | − | − |
a
Full MHC allele names are as follows: A01, Mamu-A1*001:01; A02, Mamu-A1*002:01; and B08, Mamu-B*008:01.
b
IV, intravenous; R, rectal; V, vaginal.
c
The animal had <200 CD4+ T cells/mm3.
d
Quantitative image analysis was done with both lymph node and splenic tissues.
e
−, there were not enough follicles in stained tissue sections for quantitative image analysis; ND, not done.