TABLE 1.
Macaque ID | Days postinfection | MHC genotypea and peptide | Virus | Plasma SIV RNA concn (log10 copies/ml) | Route of SIV infectionb | Phenotypee |
|||
---|---|---|---|---|---|---|---|---|---|
Ki67 | Perforin | Foxp3 | PD-1 | ||||||
Rh2515 | 42 | A01 Gag-CM9 | SIVmac239 | 4.22 | IV | ND | − | + | + |
Rh2516 | 42 | A01 Gag-CM9 | SIVmac239 | 5.55 | IV | + | ND | + | + |
Rh2520 | 42 | A01 Gag-CM9 | SIVmac239 | 7.58 | IV | + | ND | + | + |
Rh2306 | 84 | A01 Gag-CM9 | SIVmac239 | 6.15 | R | − | + | − | − |
R03111 | 105 | A02 Nef-YY9 | SIVmac239 | 6.45 | R | − | + | − | − |
R03094c | 154 | A01 Gag-CM9 | SIVmac239 | 6.20 | R | − | + | − | − |
R03116 | 161 | A01 Gag-CM9 | SIVmac239 | 3.78 | R | − | + | − | − |
11-57 | 258 | A01 Gag-CM9 | SIVmac251 | 4.51 | V | +d | + | − | + |
11-45 | 272 | A01 Gag-CM9 | SIVmac251 | 6.26 | V | ND | + | + | + |
JD85 | 272 | A01 Gag-CM9 | SIVmac251 | 4.56 | V | +d | ND | + | + |
11-89 | 349 | A01 Gag-CM9 | SIVmac251 | 5.15 | V | +d | + | + | + |
11-061 | 545 | A01 Gag-CM9 | SIVmac251 | 3.72 | V | +d | ND | + | + |
Rhax18c | 546 | B08 Nef-RL10 | SIVmac239 | 4.97 | R | +d | + | − | + |
R01106 | 567 | B08 Env-KL9 | SIVmac239 | 4.73 | R | +d | + | − | − |
Rhau10 | 1,687 | B08 Nef-RL10 | SIVmac239 | 4.11 | IV | − | + | − | − |
Full MHC allele names are as follows: A01, Mamu-A1*001:01; A02, Mamu-A1*002:01; and B08, Mamu-B*008:01.
IV, intravenous; R, rectal; V, vaginal.
The animal had <200 CD4+ T cells/mm3.
Quantitative image analysis was done with both lymph node and splenic tissues.
−, there were not enough follicles in stained tissue sections for quantitative image analysis; ND, not done.