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. 2016 Nov 29;6:37955. doi: 10.1038/srep37955

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Changes in intracellular lactate concentrations induced by increasing extracellular D-glucose from 5 to 15 mM with and without 100 nM AR-C155858 (ARC) or 50 μM phloretin (PT) measured using a lactate FRET sensor (Laconic) expressed in H441 cells. (A) Fluorescence images of mTFP (blue), Venus (yellow) and merged images in cells before and after photobleach. (B) Calculated FRET efficiency (%E). (C) FRET ratio (mTFP/Venus) in an exemplar H441 cell, over time course of treatments. (D) Collated FRET ratio data *P < 0.05, **P < 0.01, ***P < 0.001, n = 24. Data represent the means ± S.E.M.