Table 1. Minimum inhibitory and bactericidal concentrations of common and experimental anti-tuberculosis treatments against Mycobacterium tuberculosis.
| Planktonic MICa | Biofilm MICa | Planktonic MBCb | Biofilm MBCb | |
|---|---|---|---|---|
| Pyrazinamide | 50 mg/L | >1,000 mg/L | 50 mg/L | >1,000 mg/L |
| Rifampicin | 0.04 mg/L | 4 mg/L | 0.04 mg/L | 4 mg/L |
| Isoniazid | 0.04 mg/L | >256 mg/L | 0.08 mg/L | >256 mg/L |
| Ethambutol | 1 mg/L | >2,000 mg/L | 2 mg/L | >2,000 mg/L |
| Streptomycin | 0.5 mg/L | 125 mg/L | 0.5 mg/L | 1,000 mg/L |
| Amikacin | 4 mg/L | 250 mg/L | 4 mg/L | 1,000 mg/L |
| Rifabutin | 0.04 mg/L | 8 mg/L | 0.04 mg/L | 16 mg/L |
| Ascorbic acid | 700 mg/L | 2,800 mg/L | 700 mg/L | 2,800 mg/L |
| Delamanid | 0.042 mg/L | >53.45 mg/L | 0.042 mg/L | >53.45 mg/L |
| Pretomanid | 0.011 mg/L | >3.6 mg/L | 0.011 mg/L | >3.6 mg/L |
| SN30488 | 0.0056 mg/L | >4.2 mg/L | 0.0056 mg/L | >4.2 mg/L |
| QOA1 | 0.5 mg/L | >128 mg/L | 0.5 mg/L | >128 mg/L |
| QOA2 | 0.25 mg/L | >128 mg/L | 0.25 mg/L | >128 mg/L |
| QOA3 | 0.25 mg/L | >128 mg/L | 0.25 mg/L | >128 mg/L |
| 5-FAAc | 9.7 mg/L | 19.4 mg/L | 19.4 mg/L | 19.4 mg/L |
| 6-FAAc | 9.7 mg/L | 19.4 mg/L | 19.4 mg/L | 19.4 mg/L |
Notes.
a
Minimum inhibitory concentrations (MIC).
b
Minimum bactericidal concentrations (MBC) for biofilm and planktonic forms of M. tuberculosis BSG001 for a variety of experimental and non-experimental compounds.
c
Fluoroanthranilic acid.