Figure 2. Stable neuronal arbor length and increased apical and basal dendritic spine densities in LVPNs within the motor cortex of TDP-43^Q331K mutant animals.

(a,b) Show representative images of LVPN dendritic arbors from WT and TDP-43^Q331K LVPNs, respectively. (c,d) Show representative images of the apical dendritic shaft and projecting dendritic spines in WT and TDP-43^Q331K LVPNs, respectively. (e,f) Show representative images of the basal dendritic shaft and projecting dendritic spines in WT and TDP-43^Q331K LVPNs respectively. (g) Shows a scatterplot with mean ± s.e.m. of the unchanged total dendritic arbor (μm) in TDP-43^Q331K LVPNs (n = 11) compared to WT age- and litter-matched controls (n = 12), Students unpaired two-tailed t test. (h) Shows a scatterplot with mean ± s.e.m. of the unchanged apical dendritic arbor (μm) in TDP-43^Q331K LVPNs (n = 11) compared to WT age- and litter-matched controls (n = 12), Students unpaired two-tailed t test. (i) Shows a scatterplot with mean ± s.e.m. of the increased apical spine density (spines per 100 μm of dendrite) in TDP-43^Q331K LVPNs (n = 11) compared to WT age- and litter-matched controls (n = 12), *P < 0.05, Students unpaired two-tailed t test. (j) Shows a scatterplot with mean ± s.e.m. of the increased basal spine density (spines per 100 μm of dendrite) in TDP-43^Q331K LVPNs (n = 11) compared to WT age- and litter-matched controls (n = 12), *P < 0.05, Students unpaired two-tailed t test. Scale bars: (a,b) represents 100 μm; (c–f) represents 5 μm.