Figure 3. Correlation and linear relationship of spontaneous EPSC and total spine density of LVPNs from TDP-43^Q331K and WT controls.

(a) Shows WT (open circles) and TDP-43^Q331K (black squares) LVPNs that have both recorded spontaneous EPSCs and had their dendritic arbors assessed for total spine density. These variables were highly correlated (Pearson’s r²; WT: 0.92, **P = 0.002; TDP-43^Q331K: 0.64, *P = 0.03). Linear regression revealed no changes in slope between WT (black line) and TDP-43^Q331K (blue line), with hashed lines indicating respective 95% confidence intervals (P = 0.82). A runs test indicated that there were no departures from linearity in either WT (P > 0.99) nor TDP-43Q^331K (P = 0.80).