Figure 5. No observed sex differences in morphological characteristics of motor cortex LVPNs from TDP-43^Q331K and WT mice.

WT (not hashed) and TDP-43^Q331K (hashed) LVPNs were divided into groups based on gender. LVPN dendritic lengths are unchanged in total arbor length (a),apical arbor length (b) and mean basal tree length of LVPNs (c), with no significant difference between WT controls and TDP-43^Q331K LVPNs of either genotype or sex. Compared to WT LVPNs, TDP-43^Q331K LVPNs had increased total spine density (d), apical spine density (e), apical distal spine density (f) and basal spine density (i), with no difference between sexes. All data represented as mean ± s.e.m., two-way ANOVAs (female: n = 6 WT, n = 4 TDP-43^Q331K; male: WT n = 6 WT, n = 7 TDP-43^Q331K), *P < 0.05.