Table 1. EPSC and IPSC parameters of LVPNs within the motor cortex.
| Parameter | WT (n = 11) | TDP-43Q311K (n = 10) | P value |
|---|---|---|---|
| EPSC frequency (Hz) | 1.48 ± 0.23 | 3.67 ± 0.50 | **0.001a |
| EPSC amplitude (pA) | −9.89 ± 1.86 | −7.55 ± 1.96 | 0.40 |
| EPSC rise time (ms) | 3.65 ± 0.37 | 3.67 ± 0.49 | 0.97 |
| EPSC half-width (ms) | 2.93 ± 0.38 | 2.13 ± 0.35 | 0.14 |
| IPSC frequency (Hz) | 3.19 ± 0.48 | 4.38 ± 0.64 | 0.15 |
| IPSC amplitude (pA) | 25.02 ± 5.59 | 11.30 ± 6.51 | 0.12 |
| IPSC rise time (ms) | 7.31 ± 1.94 | 9.32 ± 1.30 | 0.40 |
| IPSC half-width (ms) | 7.80 ± 1.71 | 10.88 ± 3.12 | 0.39 |
| Synaptic drive ratio (E/I) | 0.52 ± 0.09 | 0.92 ± 0.12 | *0.01 |
All data presented as mean ± s.e.m., number of cells (n) in parenthesis. *P < 0.05, **P < 0.01, Student’s two-tailed unpaired t-test, excepta, Mann Whitney test.