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. 2016 Nov 29;6:37823. doi: 10.1038/srep37823

Figure 4. Reduced density of GABAergic interneurons in peri-infarct areas.

Figure 4

(a,b) Number of PV-positive (a) and SOM-positive cells (b) in 200 μm wide cortical columns, lateral (black bars) and medial (grey bars) to the ischemic lesion, 7 (PV n = 7; SOM n = 6) and 30 days post injury (PV n = 8; SOM n = 4). Compared to controls (PV n = 7; SOM n = 6), density of PV-+ neurons is significantly dampened at 30 days (one Way ANOVA, post hoc Holm-Sidak test, p < 0.05). SOM-+ cells are significantly reduced at 7 days and decrease further at 30 days. Data are mean ± SE. *p < 0.05; **p < 0.01. (c,d) Representative low magnification images of PV (c) and SOM immunostaining (d) in the motor cortex. Images were taken from sham animals and from the perilesional areas of mice at 7 and 30 days post-infarct. Column width = 200 μm.