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. 2016 Nov 29;6:37848. doi: 10.1038/srep37848

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Haematoxylin/eosin (H/E)-stained sections showing a large portion (~72%) of the blood cells in the flow-recovered artery from a CNR 4 Gy-treated mouse (a) compared to the remaining occlusive thrombus in the artery from a proton-only 4 Gy-treated mouse (b). A typical flow-recovered artery from a CNR-4 Gy mouse that received 300 mg of Fe₃O₄/kg BW 24 hours prior to proton irradiation (c). The inhomogeneous distribution of IONs was demonstrated by the H/E staining of a sectioned artery. No structural damage, such as rupture or intimal thickening, was observed, despite the presence of nanoparticles near or attached to the wall with an inhomogeneous distribution.