Table 6. Therapeutic efficacy of hydroxychavicol in a guinea pig model of tinea corporis (dermatophytosis)^a.

Treatment	No. of animals with positive culture/total no. of animals (%)	Average fungal burden of the five infected animals
Untreated control	5/5 (100)	+10.0
Vehicle–treated control	5/5 (100)	+10.0
0.25% hydroxychavicol	0/5 (0)	0

^aTreatment (200 μl per loci of infected animal site and two loci per animal) was started twice–a–day on day–3 (after the 72 h) postinfection of T. mentagrophytes var. interdigitale ATCC 9533 and was continued for ten consecutive days. The culture study was carried out two days (48 h) after the last treatment (on day–14 postinfection). The results are representative of two different experiments with similar results each time.