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Clinical example of SPIONs used in MRI. Prostate cancer patient was injected with SPIONs and imaged 24 h later. Oblique sagittal T2*-weighted gradient-echo MR image shows normal lymph node as black (top) but metastatic lymph node as hyperintense (bottom) because it does not incorporate as many SPIONs. Without image guidance, this positive node would be excluded from pelvic lymph node dissection. (Reprinted with permission of (27).)
