TABLE 2.

Clinical Trials Using Nanoparticles

Type	Size (nm)	Agent and modality	Motivation	Indication	Trial
Sulfur colloid	<220	99mTc, SPECT	Map lymph nodes during rectal surgery	Colon cancer	NCT02112240
Sulfur colloid	<220	99mTc, SPECT	Raise pH of contrast agent to minimize pain	Cancer	NCT01660412
Sulfur colloid	<220	99mTc, SPECT	Map lymph nodes during rectal surgery	Head and throat cancer	NCT00012168
Gold	150	Nanoshell, photothermal	Increase local heating better than by laser alone	Head and neck cancer	NCT00848042
Silica	3–10	124I and Cy5, PET and optical	Define sentinel lymph nodes	Melanoma	NCT01266096
Iron oxide	17–30	Ferumoxytol, MRI	Monitor response to bevacizumab therapy	Glioma	NCT00769093
Iron oxide	17–30	Ferumoxytol, MRI	Localize lymph node metastases	Pancreatic cancer	NCT00920023
Iron oxide	80–150	Ferumoxide, MRI	Identify presence of implanted stem cells	Inflammation	NCT01169935
Iron oxide	17–30	Ferumoxytol, MRI	Detect recent myocardial infarction	Myocardial infarction	NCT01995799