Table 1. Proteins significantly different between exosomes from Mtb-infected and control macrophages.
| Identified Proteins | Infected NSAF | Control NSAF | p value NSAF-inf versus NSAF-control | Fold Change NSAF-inf/NSAF-control |
|---|---|---|---|---|
| 60 S acidic ribosomal protein P0 | 0.064 | 0.000 | 0.00012 | INF |
| Coronin-1C | 0.023 | 0.000 | 0.00017 | INF |
| Lupus La protein | 0.023 | 0.000 | 0.00019 | INF |
| Heterogeneous nuclear ribonucleoprotein K | 0.075 | 0.003 | 0.00029 | 28.4 |
| Heat shock 70 kDa protein 4 | 0.013 | 0.000 | 0.00031 | INF |
| Alanine-tRNA ligase, cytoplasmic | 0.006 | 0.000 | 0.00035 | INF |
| Calreticulin | 0.017 | 0.000 | 0.001 | INF |
| Protein disulfide-isomerase A3 | 0.040 | 0.000 | 0.002 | INF |
| L-amino-acid oxidase | 0.018 | 0.000 | 0.003 | INF |
| Moesin | 0.151 | 0.062 | 0.0032 | 2.4 |
| Nucleolin | 0.063 | 0.007 | 0.0032 | 8.6 |
| Vimentin | 0.251 | 0.072 | 0.0034 | 3.5 |
| Protein disulfide-isomerase A6 | 0.046 | 0.003 | 0.0035 | 16.6 |
| Spliceosome RNA helicase DDX39B | 0.027 | 0.000 | 0.0039 | INF |
| Fermitin family homolog 3 | 0.046 | 0.002 | 0.0047 | 19.8 |
| Programmed cell death 6-interacting protein | 0.005 | 0.000 | 0.0047 | INF |
| S-adenosylmethionine synthase isoform type-2 | 0.029 | 0.000 | 0.0048 | INF |
| Glyceraldehyde-3-phosphate dehydrogenase | 0.293 | 0.201 | 0.0059 | 1.5 |
| ATP-dependent RNA helicase A | 0.005 | 0.000 | 0.0068 | INF |
| 60 kDa heat shock protein, mitochondrial | 0.013 | 0.000 | 0.0082 | INF |
| Cytosol aminopeptidase | 0.041 | 0.000 | 0.0084 | INF |
| Ubiquitin-like modifier-activating enzyme 1 | 0.056 | 0.007 | 0.0089 | 8.5 |
| ITIH4 protein | 0.011 | 0.000 | 0.01 | INF |
| Serine/threonine-protein phosphatase 2 A 65 kDa regulatory subunit A alpha isoform | 0.011 | 0.002 | 0.011 | 7.0 |
| Tryptophan-tRNA ligase, cytoplasmic | 0.031 | 0.000 | 0.011 | INF |
| Transketolase | 0.082 | 0.015 | 0.012 | 5.6 |
| Zyxin (Fragment) | 0.007 | 0.000 | 0.012 | INF |
| Heat shock protein HSP 90-beta | 0.361 | 0.221 | 0.014 | 1.6 |
| Tyrosine-tRNA ligase, cytoplasmic | 0.014 | 0.000 | 0.017 | INF |
| 6-phosphogluconate dehydrogenase, decarboxylating | 0.075 | 0.021 | 0.024 | 3.6 |
| X-ray repair cross-complementing protein 6 | 0.061 | 0.004 | 0.026 | 13.8 |
| 78 kDa glucose-regulated protein | 0.109 | 0.047 | 0.028 | 2.3 |
| Eukaryotic initiation factor 4A-I | 0.115 | 0.038 | 0.028 | 3.1 |
| Thrombospondin-4 | 0.011 | 0.002 | 0.028 | 6.2 |
| Bifunctional purine biosynthesis protein PURH | 0.028 | 0.000 | 0.028 | INF |
| Staphylococcal nuclease domain-containing protein 1 | 0.012 | 0.001 | 0.031 | 9.2 |
| Heat shock cognate 71 kDa protein | 0.443 | 0.273 | 0.036 | 1.6 |
| Integrin beta-1 | 0.006 | 0.000 | 0.046 | INF |
| UDP-glucose 6-dehydrogenase | 0.013 | 0.000 | 0.046 | INF |
| Purine nucleoside phosphorylase | 0.039 | 0.000 | 0.048 | INF |
| Lamin-B1 | 0.021 | 0.003 | 0.049 | 6.5 |
| Transforming growth factor-beta-induced protein ig-h3 | 0.061 | 0.128 | 0.0047 | 0.5 |
| Palmitoyl-protein thioesterase 1 | 0.053 | 0.106 | 0.033 | 0.5 |
| Complement C4-A | 0.056 | 0.073 | 0.035 | 0.8 |
INF: When the value in the denominator is zero (the fold change is the normalized spectral abundance factor23 (NSAF)-infected divided by NSAF-control), *p value from t-test comparing the averages of three independent experiments between NSAF-infected versus NSAF-control.