Table 3.
Characteristics of cefotaxime-resistant Enterobacteriaceae strains collected in intestinal flora of ICU-patients and their transconjugants.
| Strain | Resistance profile to non-beta-lactams | ESBL genes | Associated bla genes |
|---|---|---|---|
| Kp6 | GEN, AMK, TOB, NET, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-1, blaOXA-48 |
| TCKp6 | GEN, TOB, NET, AMK | blaCTX-M-15 | blaTEM-1, blaOXA-1 |
| Kp10 | GEN, AMK, TOB, NET, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-1, blaOXA-48 |
| TCKp10 (1) | GEN, TOB, NET, AMK, TET | blaCTX-M-15 | blaTEM-1, blaOXA-1 |
| TCKp10 (2) | None | None | blaOXA-48 |
| Kp15b | GEN, AMK, TOB, NET, MNO, TET, NAL, CIP, CHL, SXT | blaCTX-M-14 | blaSHV-1, blaTEM-1, blaOXA-48 |
| Kp19b | GEN, AMK, TOB, NET, MNO, TET, NAL, CIP, CHL | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-48 |
| Kp7 | GEN, TOB, NET, MNO, TET, NAL, CIP, CHL, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaCMY-4 |
| TCKp7 | TET, CHL, SXT | None | blaCMY-4 |
| Kp13 | GEN, TOB, NET, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaNDM−1, blaSHV-1, blaTEM-1, blaOXA-1 |
| TCKp13 | GEN, TOB, NET | blaCTX-M-15 | blaNDM-1, blaTEM-1, blaOXA-1 |
| Kp14b | GEN, TOB, NET, MNO, TET, NAL, CHL, SXT | blaCTX-M-15 | blaNDM-1, blaSHV-1, blaTEM-1, blaOXA-1 |
| Kp22 | GEN, TOB, NET, MNO, TET, CIP, SXT | blaCTX-M-15 | blaNDM-1, blaSHV-1, blaTEM-1, blaOXA-1 |
| TCKp22 | GEN, TOB | blaCTX-M-15 | blaNDM-1, blaTEM-1, blaOXA-1 |
| Kp2 | GEN, TOB, NET, MNO, TET, NAL, CIP, FOS, SXT | blaCTX-M-15 | blaNDM-1, blaSHV-1, blaTEM-1, blaOXA-1 |
| TCKp2 | GEN, TOB | blaCTX-M-15 | blaNDM-1, blaTEM-1, blaOXA-1 |
| Kp16b | GEN, NET, MNO, NAL, CIP, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1 |
| Kp9 | GEN, AMK, TOB, NET, MNO, TET, NAL, CIP, FOS, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-1, blaOXA-48 |
| TCKp9 (1) | TET, TOB, NET, AMK, FOS | blaCTX-M-15 | blaTEM-1, blaOXA-1 |
| TCKp9 (2) | FOS | None | blaOXA-48 |
| Kp12 | GEN, TOB, NET, MNO, TET, CIP, CHL, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-48 |
| TCKp12 | None | None | blaOXA-48 |
| Kp20 | GEN, AMK, TOB, NET, NAL, CIP, FOS | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-1, blaOXA-48 |
| TCKp20 (1) | TET, GEN, TOB, NET | blaCTX-M-15 | blaTEM-1, blaOXA-1 |
| TCKp20 (2) | None | None | blaOXA-48 |
| Kp21 | GEN, AMK, TOB, NET, MNO, TET, NAL, CIP, CHL | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-1, blaOXA-48 |
| TCKp21 (1) | GEN, TOB, NET, AMK, FOS | blaCTX-M-15 | blaTEM-1, blaOXA-1 |
| TCKp21 (2) | FOS | None | blaOXA-48 |
| Kp25 | GEN, TOB, AMK, NET, CIP, NAL, TET | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-1, blaOXA-48 |
| TCKp25 | TET, GEN, TOB, AMK, FOS | blaCTX-M-15 | blaTEM-1, blaOXA-1 |
| Kp23b | GEN, AMK, TOB, NET, MNO, TET, NAL, CIP, FOS, CHL, SXT | blaCTX-M-14 | blaSHV-1, blaTEM-1, blaOXA-48 |
| Kp17 | GEN, AMK, TOB, NET, TET, NAL, CIP, FOS, CHL, SXT | blaCTX-M-14 | blaSHV-1, blaTEM-1, blaOXA-48 |
| TCKp17 | None | None | blaOXA-48 |
| Kp18b | GEN, TOB, NET, TET, NAL, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaOXA-48 |
| Kp5 | GEN, TOB, NET, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaSHV−1, blaTEM-1, blaCMY-4, blaOXA48 |
| TCKp5 | TET | None | blaOXA−48,blaCMY-4 |
| Kp1 | GEN, TOB, NET, MNO, TET, NAL, CIP, FOS, SXT | blaCTX-M-15 | blaNDM-1, blaSHV-1, blaTEM-1, blaOXA-1 |
| TCKp1 | GEN, TOB | blaCTX-M-15 | blaNDM-1, blaTEM-1, blaOXA-1 |
| Kp11 | GEN, TOB, NET, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaNDM-1, blaSHV-1, blaTEM-1, blaOXA-1 |
| TCKp11 | GEN, TOB | blaCTX-M-15 | blaNDM-1, blaTEM-1, blaOXA-1 |
| Kp4 | AMK, TOB, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1, blaCMY-4 |
| TCKp4 | TET, SXT | None | blaCMY-4 |
| Kp3b | GEN, TOB, NET, NAL, CIP, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1 |
| Kp24b | TOB, NET, TET, NAL, CIP, SXT | blaCTX-M-15 | blaTEM-1 |
| Kp8b | TOB, NET, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaSHV-1, blaTEM-1 |
| Ec7 | None | blaCTX-M-15 | blaSHV-1 |
| TCEc7 | None | blaCTX-M-15 | None |
| Ec4b | GEN, TOB, NET, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaSHV-1 |
| Ec3 | MNO, TET, CHL, SXT | blaCTX-M-15 | blaTEM-1 |
| TCEc3 | None | blaCTX-M-15 | None |
| Ec5 | GEN, TOB, MNO, TET, NAL, CIP, SXT | blaCTX-M-15 | blaOXA-1 |
| TCEc5 | GEN, TOB, TET, SXT | blaCTX-M-15 | blaOXA-1 |
| Ec6b | TET, NAL, CIP, NOR, SXT | blaCTX−M−27 | None |
| Ec1b | NAL, CIP | blaCTX-M-15 | None |
| Ec2b | MNO, TET, NAL, CIP, CHL, SXT | blaCMY−2a | None |
| Ecl3b | GEN, TOB, MNO, NAL, CIP, NOR, CHL, SXT | blaCTX-M-15 | blaTEM-1 |
| Ecl2b | GEN, TOB, NET, MNO, TET, NAL, CIP, CHL, SXT | blaCTX-M-15 | blaTEM-1, blaOXA-1 |
| Ecl1 | GEN, TOB, NET, MNO, TET, NAL, CIP, CHL, SXT | blaCTX-M-15 | blaTEM-1 |
| TCEcl1 | TET, GEN, TOB, CHL, SXT | blaCTX-M-15 | blaTEM-1, blaOXA-1 |
Ecl, Enterobacter cloacae; Kp, Klebsiella pneumoniae; Ec, E. coli; NAL, nalidixic acid; CIP, ciprofloxacin; SXT, trimethoprim-sulfamethoxazole; TET, tetracyclin; MNO, minocyclin; GEN, gentamicin; TOB, tobramycin; AMK, amikacin; NET, netilmicin, CHL, chloramphenicol; FOS, fosfomycin; ND, not determined; ESBL, extended-spectrum-beta-lactamase; TC, Transconjugant.
a
plasmidic AmpC producing-strain (CMY-2 type) but none ESBL producer.
b
resistance transfer was not obtained.