Table 1.
Replicated associations between CHRN genes and nicotine dependence.
| SNP | Gene | p | Ref. | p | Ref. | p | Ref. | p | Ref. | p | Ref. | p | Ref. | p | Ref. | p | Ref. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs10958725 | CHRNB3-A6 | 3.1 × 10−8 | [54] | 4.7 × 10−3 | [55] | 3.6 × 10−5 | [55] | ||||||||||
| rs10958726 | CHRNB3-A6 | 1.2 × 10−7 | [54] | 9.6 × 10−5 | [56] | 5.7 × 10−3 | [57] | 1.1 × 10−3 | [57] | 1.1 × 10−2 | [55] | 1.4 × 10−5 | [55] | ||||
| rs13273442 | CHRNB3-A6 | 1.4 × 10−7 | [54] | 2.0 × 10−2 | [58] | 1.4 × 10−3 | [58] | 3.0 × 10−2 | [58] | ||||||||
| rs4736835 | CHRNB3-A6 | 3.0 × 10−8 | [54] | 6.0 × 10−3 | [55] | 6.2 × 10−3 | [57] | ||||||||||
| rs1955186 | CHRNB3-A6 | 8.3 × 10−5 | [56] | 5.4 × 10−3 | [57] | 1.1 × 10−2 | [57] | ||||||||||
| rs1955185 | CHRNB3-A6 | 4.6 × 10−8 | [54] | 1.0 × 10−4 | [56] | 1.1 × 10−5 | [55] | 5.4 × 10−3 | [57] | 1.2 × 10−3 | [57] | ||||||
| rs13277254 | CHRNB3-A6 | 4.0 × 10−3 | [59] | 4.0 × 10−5 | [56] | 7.8 × 10−4 | [57] | 6.3 × 10−4 | [60] | ||||||||
| rs13277524 | CHRNB3-A6 | 6.0 × 10−5 | [56] | 3.8 × 10−3 | [57] | 7.4 × 10−4 | [57] | ||||||||||
| rs6474412 | CHRNB3-A6 | 1.1 × 10−4 | [56] | 5.6 × 10−3 | [57] | 1.0 × 10−3 | [61] | 8.7 × 10−3 | [55] | 2.1 × 10−5 | [55] | * 1.7 × 10−4 | [62] | * 2.6 × 10−5 | [62] | * 8.0 × 10−3 | [63] |
| rs6474413 | CHRNB3-A6 | 3.6 × 10−8 | [54] | 6.3 × 10−5 | [56] | 9.3 × 10−4 | [57] | ||||||||||
| rs7004381 | CHRNB3-A6 | 9.9 × 10−8 | [54] | 3.9 × 10−2 | [60] | 3.1 × 10−3 | [57] | ||||||||||
| rs4950 | CHRNB3-A6 | 9.5 × 10−8 | [54] | 1.0 × 10−4 | [56] | 1.4 × 10−3 | [57] | 7.0 × 10−3 | [60] | 1.1 × 10−5 | [55] | ||||||
| rs13280604 | CHRNB3-A6 | 1.0 × 10−7 | [54] | 6.0 × 10−3 | [60] | 1.4 × 10−5 | [55] | * 1.2 × 10−4 | [62] | * 2.7 × 10−5 | [62] | ||||||
| rs4952 | CHRNB3-A6 | 4.1 × 10−3 | [56] | 1.1 × 10−2 | [57] | 1.4 × 10−3 | [57] | 2.0 × 10−2 | [58] | ||||||||
| rs4954 | CHRNB3-A6 | 4.3 × 10−7 | [64] | 6.0 × 10−3 | [65] | 4.1 × 10−3 | [57] | ||||||||||
| rs16969968 | CHRNA5-A3-B4 | 1.0 × 10−2 | [59] | 1.3 × 10−4 | [56] | * 2.4 × 10−69 | [62] | * 5.6 × 10−72 | [66] | * 9.0 × 10−4 | [67] | * 4.3 × 10−65 | [68] | 5.1 × 10−17 | [69] | ||
| rs1051730 | CHRNA5-A3-B4 | 2.0 × 10−4 | [56] | 2.0 × 10−3 | [70] | * 5.8 × 10−44 | [68] | * 2.8 × 10−73 | [66] | * 1.0 × 10−3 | [67] | * 1.7 × 10−66 | [68] | * 6.0 × 10−20 | [71] | 4.3 × 10−17 | [69] |
| rs6495308 | CHRNA5-A3-B4 | 1.9 × 10−3 | [56] | * 6.9 × 10−5 | [72] | 4.8 × 10−3 | [56] | 1.7 × 10−7 | [69] | ||||||||
| rs2236196 | CHRNA4 | 3.1 × 10−7 | [64] | 2.0 × 10−2 | [73] | 5.0 × 10−4 | [57] | 4.4 × 10−4 | [57] | 2.7 × 10−2 | [69] |
p. p-value; Ref. reference. * associations with cigarettes per day (CPD). The associations identified by GWASs were underlined.