Table 2.

Significant expression correlation between CHRNs and dopaminergic and GABAergic receptor genes in human brain.

Genes	CHRNB3	CHRNA6	CHRNA5	CHRNA3	CHRNB4	CHRNA4
DRD1	SNIG	PUTM,TCTX		FCTX,TCTX		FCTX,THAL
DRD2	SNIG,TCTX	PUTM,SNIG,TCTX,THAL		FCTX,HIPP,TCTX,THAL	CRBL,FCTX	CRBL,OCTX,SNIG,TCTX,THAL
DRD3	FCTX	PUTM	THAL	FCTX	FCTX,OCTX
DRD4	FCTX		THAL	FCTX,TCTX	FCTX,HIPP,OCTX,PUTM,TCTX
DRD5	WHMT	THAL	THAL	FCTX,THAL,WHMT	CRBL,FCTX,HIPP,SNIG,WHMT	THAL
TH	SNIG,TCTX,WHMT	SNIG,TCTX		FCTX,TCTX	CRBL,FCTX,OCTX	CRBL,SNIG
GABRA1	SNIG	SNIG,THAL	SNIG,THAL	CRBL,THAL	FCTX	FCTX,HIPP,MEDU,SNIG,THAL
GABRA2	OCTX	MEDU,OCTX,PUTM,THAL	CRBL,MEDU	FCTX,MEDU,TCTX,THAL	FCTX,MEDU	OCTX,THAL
GABRA3	OCTX,SNIG	MEDU,OCTX,SNIG,THAL	MEDU,SNIG,THAL	CRBL,THAL		CRBL,FCTX,HIPP,OCTX,PUTM,SNIG,TCTX,THAL
GABRA4	FCTX,OCTX,SNIG,THAL	MEDU,OCTX,PUTM,SNIG,THAL,WHMT	CRBL,MEDU,THAL	FCTX,MEDU,TCTX,THAL,WHMT	FCTX,MEDU,TCTX	CRBL,FCTX,HIPP,SNIG,THAL
GABRA5	OCTX	MEDU,OCTX,THAL	MEDU,THAL	MEDU,THAL	CRBL	CRBL,FCTX,OCTX,THAL
GABRA6				CRBL
GABRB1	FCTX,OCTX,PUTM,SNIG	MEDU,PUTM,SNIG,THAL	CRBL,MEDU,SNIG	FCTX,OCTX,TCTX	FCTX,TCTX	OCTX,SNIG
GABRB2	SNIG	SNIG,THAL	CRBL,THAL	CRBL,FCTX,PUTM,TCTX,THAL	FCTX,TCTX	FCTX,HIPP,MEDU,THAL
GABRB3	OCTX,SNIG	MEDU,OCTX,SNIG,THAL	MEDU,THAL	MEDU,TCTX,THAL	MEDU,TCTX	CRBL,FCTX,OCTX,SNIG,THAL
GABRD	WHMT	THAL	THAL	CRBL,PUTM,THAL,WHMT		FCTX,HIPP,MEDU,THAL
GABRE		THAL				MEDU
GABRG1		MEDU	CRBL,MEDU	MEDU,OCTX
GABRG2	OCTX,SNIG,WHMT	SNIG,THAL	THAL	CRBL,TCTX,THAL	TCTX	FCTX,HIPP,MEDU,SNIG,THAL
GABRG3	FCTX	MEDU,PUTM	CRBL	TCTX	FCTX,TCTX	CRBL,FCTX,MEDU
GABRP	FCTX,PUTM			FCTX	CRBL,FCTX,PUTM
GABRQ	HIPP	THAL	THAL	HIPP,THAL	CRBL	CRBL,MEDU,PUTM,THAL
GABRR2				THAL

α = 3.3 × 10⁻⁵. Cerebellar cortex (CRBL), frontal cortex (FCTX), hippocampus (HIPP), medulla (specifically inferior olivary nucleus, MEDU), occipital cortex (specifically primary visual cortex, OCTX), putamen (PUTM), substantia nigra (SNIG), temporal cortex (TCTX), thalamus (THAL), and intralobular white matter (WHMT). These six CHRN genes were detected in ten human brain areas. In many areas, their expression was significantly correlated with the dopaminergic or GABAergic expression (p < α) (Table 2). The correlation coefficients (0.358 ≤ |r| ≤ 0.920), regression coefficients (0.008 ≤ |β| ≤ 0.749) and p values (3.9 × 10⁻⁴² ≤ p ≤ 3.3 × 10⁻⁵) for these correlations are shown in the Supplementary Tables S1 and S2.