Table 3.
MRI findings in PCNSL and GBM at the time of initial evaluation
| MRI finding | PCNSL | GBM | p-value | |
|---|---|---|---|---|
| Localization | only supratentorial | 66.7% | 98.1% | <0.001 |
| only infratentorial | 5.5% | 1.9% | 0.308 | |
| supra- and infratentorial | 27.7% | 0% | <0.001 | |
| Type of lesions | solitary demarcated lesion | 3.7% | 13% | 0.046 |
| solitary infiltrative type | 20.4% | 51.9% | 0.121 | |
| multiple infiltrative lesions | 51.9% | 35.2% | 0.081 | |
| diffuse infiltrative type | 24.1% | 0% | <0.001 | |
| Type of enhancement | homogeneous | 64.8% | 0% | <0.001 |
| nonhomogeneous | 14.8% | 98.1% | <0.001 | |
| diffuse infiltrative – worm-like, patchy, stripy… | 20.4% | 0% | <0.001 | |
| presence of necrosis | 5.6% | 88.9% | <0.001 | |
| Involvement of brain surface | without reaching brain surface | 12.9% | 11.1% | 0.567 |
| reaching brain surface | 87% | 88.9% | 0.846 | |
| meningeal infiltration | 35.2% | 46.3% | 0.240 | |
| ependymal infiltration | 53.7% | 37% | 0.054 | |
| Optic nerves, chiasma or tracts involvement | 42.6% | 5.6% | <0.001 | |
| Cranial nerves involvement (optical nerves and tracts excluded) | 5.6% | 0% | 0.079 | |
| Corpus callosum infiltration | 42.6% | 44.4% | 0.846 | |
| Butterfly pattern | 24.1% | 14.8% | 0.224 | |
| Basal ganglia involvement | 55.6% | 18.5% | <0.001 | |
| Cerebral cortex involvement | 83.3% | 51.9% | <0.001 | |
| aDWI | free diffusion | 1.9% | 10.4% | 0.189 |
| restricted diffusion in some part of the solid | 97% | 89.6% | 0.189 | |
| Signs of bleeding | 5.6% | 44.4% | <0.001 | |
| Presence of vasogenic edema | 92.6% | 83.3% | 0.139 | |
aDWI was available in 35 PCNSL patients and 51 GBM patients. Statisticaly significant results are in bold (p less than 0.05)