Figure 1. Comparison of viral load measurements (filled circles, solid black lines) with best-fit model predictions (solid colored lines).

Each green line shows the predicted viral load over time, normalized by its initial amount, V_P(t)/V_P(0), in a model whereby antibody can only neutralize free virus particles. Each purple line shows a modified model whereby antibody can also lead to clearance of infected cells. Only those patients with a day 1 viral load lower than baseline are shown. Open circles and dashed black lines represent data points that were not used for parameter estimation. Within each subfigure, we note the quantity Δlog₁₀V_P(t_min) = log₁₀(V_P,min/V_P(0)), i.e. the viral load at the nadir and the time in days at which this occurs for the data (black letters), and the predictions for a model with free virus clearance only (green) and a model that also includes infected cell clearance (purple). This predicted minimum for each patient and model is denoted with a star.