Skip to main content
. Author manuscript; available in PMC: 2016 Nov 29.
Published in final edited form as: Science. 2016 May 5;352(6288):1001–1004. doi: 10.1126/science.aaf1279

Figure 2. bNAbs accelerate clearance of HIV-1-infected cells in vivo.

Figure 2

(A) Scatter plot showing the percentage of Gag+ cells among CD3+CD8− cells in 3BNC117 (600 μg) or isotype control treated mice 5 hours after HIVYU2-infected cell transfer.

(B) Percentage of Gag+ cells among CD3+CD8− cells in bNAbs (3BNC117 + 10–1074, 300 μg each) or isotype control treated mice 5 hours after HIVYU2-infected cell transfer (left panel). Cell-associated HIV-1 RNA was measured in enriched human cells extracted from the spleen of mice 5 hours after transfer, plotted as the ratio of HIV-1 RNA to the number of CD3+CD8− cells for each mouse (right panel).

(C) Graphs represent transfer experiments with cells infected by HIV2C1, HIV2C5, HIV2D3, or HIV2E5. Each dot represents one mouse. Lines represent median values. Data represent 2–4 independent experiments with a total of 6–13 mice per condition. *P<0.05; **P<0.005; ***P<0.001, two-tailed Mann–Whitney U test.