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. Author manuscript; available in PMC: 2016 Nov 29.
Published in final edited form as: Science. 2016 May 5;352(6288):1001–1004. doi: 10.1126/science.aaf1279

Figure 3. FcγR engagement is required to facilitate clearance of HIV-1-infected cells.

Figure 3

(A) Percentage of Gag+ cells among CD3+CD8− cells in bNAbs, GRLR-bNAbs, or isotype control treated mice.

(B) NRG mice were injected with mouse FcγRII/III/IV blocking antibodies or isotype control 6 hours before injection of bNAbs. Graphs show the percentage of Gag+ cells among CD3+CD8− cells.

(C) Percentage of Gag+ cells among CD3+CD8− cells in mice receiving FcγRIV blocking antibody, or isotype control.

(D) Infected cell clearance in chronically HIV-1YU2-infected hu-mice. Scatter plot shows the ratio of the percentage of Gag+ cells among CD3+CD8− cells before and 5 hours after 3BNC117, GRLR-3BNC117, or isotype control injection. Each dot represents one mouse. Lines represent median values. Data represent 2–4 independent experiments for each condition with a total of 7–12 mice per condition. *P<0.05; **P<0.005; ***P<0.001, two-tailed Mann–Whitney U test.